What is oxidative deamination


While enzymatic forms of this reaction are important in maintaining nitrogen balance, oxidative deamination can also occur as an enzymatic reaction, where the deamination of lysine can be catalyzed by the enzyme lysine oxidase. Oxidative deamination is also the first step in the breakdown of norleucine and structurally related non-standard amino acids such as norvaline, beta-methylnorleucine, and homoisoleucine.

For example, oxidative deamination of norleucine would yield ketocaproic acid and ammonia.

Akagawa et al., used model reactions of benzylamine to elucidate oxidative deamination by glycoxidation.

The oxidative reaction was inhibited by EDTA, catalase, and dimethyl sulfoxide,

suggesting the participation of reactive oxygen species in this process. They proposed a

Strecker-type reaction and reactive oxygen species-mediated oxidation during

glycoxidation as a mechanism for oxidative deamination.

When the enzyme lysyl oxidase crosslinks collagen, for example, hydrogen peroxide is released. However, enzymatic deamination reactions involving oxidases may be attenuated by endogenous protective mechanisms.

Related Articles
  • What does oxidation mean
    Credit:Bill AbbottCC-BY-SA 2.0Not all oxidation is negative. Oxidation is essential to the body’s metabolism of food for energy. Wine begins oxidizing ...
  • There are three types of alcohols, which are classified based on the number of hydrogen atoms bonded to the carbon atom that is bonded to the oxygen a ...
  • What is oxidized sterling silver
    Credit:Homini:)CC-BY-2.0Pure silver must generally be polished and cleaned on a regular basis to keep it from becoming tarnished. It should not be pla ...
  • What causes oxidation
    Credit:Bill AbbottCC-BY-2.0When oxygen in the air reacts with the molecules that make up many substances, the result is often destructive. Rust forms ...
  • It is generally the case that only weakly acidic or non-acidic metal oxides form metal hydroxides when in contact with water. The oxides that react in ...
  • Because electrons are neither created nor destroyed in a chemical reaction, it is impossible to have oxidation without another reactant undergoing red ...
You Might Also Like